Successful Treatment of Disseminated Acanthamoeba sp. Infection with Miltefosine

Abstract

We report on an HIV-negative but immunocompromised patient with disseminated acanthamoebiasis, granulomatous amoebic encephalitis, and underlying miliary tuberculosis and tuberculous meningitis. The patient responded favorably to treatment with miltefosine, an alkylphosphocholine. The patient remained well with no signs of infection 2 years after treatment cessation.

Keywords

• Acanthamoeba
• granulomatous Acanthamoeba encephalitis (GAE)
• tuberculosis
• immunocompromised non–HIV-infected patient
• miltefosine
• dispatch