Nature Communications (Nov 2021)

Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes

  • Guillermo Abascal-Palacios,
  • Laura Jochem,
  • Carlos Pla-Prats,
  • Fabienne Beuron,
  • Alessandro Vannini

DOI
https://doi.org/10.1038/s41467-021-27338-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Ty3 retrotransposon integrates with an exquisite specificity upstream of RNA Polymerase III-transcribed genes, such as transfer RNAs. Here the authors resolve a cryo-EM structure of an active Ty3 intasome in complex with a TFIIIB-bound tRNA promoter, shedding light into the molecular determinants of harmless retrotransposition.