In this work, we discuss the deconfinement phase transition to quark matter in hot/dense matter. We examine the effect that different charge fractions, isospin fractions, net strangeness, and chemical equilibrium with respect to leptons have on the position of the coexistence line between different phases. In particular, we investigate how different sets of conditions that describe matter in neutron stars and their mergers, or matter created in heavy-ion collisions affect the position of the critical end point, namely where the first-order phase transition becomes a crossover. We also present an introduction to the topic of critical points, including a review of recent advances concerning QCD critical points.
