The influence of dysregulated lipid metabolism on the progression of Parkinson's disease and its clinical implications

Abstract

Lipid metabolism may play a role in the onset and progression of Parkinson's disease （PD）, involving various pathological mechanisms such as abnormal folding and accumulation of α‑synuclein (α‑Syn), ferroptosis, GBA1 gene mutation, and mitochondrial dysfunction, etc.. This article reviews the lipid metabolism abnormalities associated with Parkinson's disease and explores potential related pathophysiological mechanism, aiming to provide new insights into the early diagnosis and treatment of Parkinson's disease.

Keywords

• parkinson disease
• lipid metabolism
• alpha ‑ synuclein
• glucosylceramidase
• genes
• mutation
• review