Complete remission with immunotherapy: Case report of a patient with metastatic bladder cancer to the humerus

Abstract

Bladder cancer is the sixth most common malignancy in the United States. Cisplatin combination regimens are first line therapy for patients with metastatic urothelial bladder cancer who are eligible candidates and no treatments have shown to improve outcome compared to chemotherapy for the past 20 years. Significant advances were made in past 2–3 years and the most significant was the introduction of checkpoints inhibitors in bladder cancer treatment. We present a patient diagnosed with metastatic urothelial carcinoma who progressed while on cisplatin/gemcitabine chemotherapy in the form of oligometastasis to the bone. He has achieved a durable complete response with atezolizumab. Keywords: Metastatic urothelial cancer, Cisplatin chemotherapy, Atezolizumab, Checkpoint inhibitors, PD-1/PD-L1