Biochemistry Research International (Jan 2024)

Comparative Analysis of Phytochemicals and Antioxidant Characterization Among Different Parts of Catharanthus roseus: In Vitro and In Silico Investigation

  • Farjana Akter Hira,
  • Ashekul Islam,
  • Kanika Mitra,
  • Ummey Hafsa Bithi,
  • Khondoker Shahin Ahmed,
  • Sanzida Islam,
  • Shaike Mohammad Abdullah,
  • Md. Nazim Uddin

DOI
https://doi.org/10.1155/2024/1904029
Journal volume & issue
Vol. 2024

Abstract

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Conclusions: The mixed-solvent extract had higher levels of catechin hydrate, rutin hydrate, trans-ferulic acid, and vanillic acid, whereas the ethanol extract contained more (−) epicatechin, catechol, kaempferol, quercetin, and trans-cinnamic acid. While the extracts displayed antioxidant activity, the phytoconstituents also inhibited ROS-generating mPGES-1. These results identify key compounds with potential for developing new chemotherapeutic agents against ROS.