Efficacy of a Neuroimmune Therapy Including Pineal Methoxyindoles, Angiotensin 1-7, and Endocannabinoids in Cancer, Autoimmune, and Neurodegenerative Diseases

Abstract

Paolo Lissoni,1 Franco Rovelli,1 Alejandra Monzon,1 Giusy Messina,1 Nicoletta Merli,1 Rosanna Tartarelli,2 Simonetta Tassoni,2 Francesca Zecchinato,3 Ana Cristina Simoes-e-Silva,4 Agnese Valentini,5 Giuseppe Di Fede,1 Daniel P Cardinali6 1Institute of Biological Medicine/International Institute of PNEI, Milan, Italy; 2PNEI Psychological Service, Pietrasanta, Lucca, Italy; 3Biotherapy Service, Verona, Italy; 4Facultade de Medicina, Belo Horizonte, Brazil; 5Madonna del Soccorso Hospital, San Benedetto del Tronto, Ascoli-Piceno, Italy; 6Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Buenos Aires, ArgentinaCorrespondence: Daniel P Cardinali, Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Av Moreau de Justo 1300, Buenos Aires, C1107AFA, Argentina, Email [email protected]; [email protected]: Recent advancements in psycho-neuro-endocrine-immunology indicate that numerous noncommunicable diseases (NCDs) originate from disruptions in the cytokine immune network, resulting in chronic inflammatory responses. This persistent low-degree inflammation is attributed to deficiencies in crucial endogenous anti-inflammatory neuroendocrine systems, including the pineal gland, the endocannabinoid system, and the angiotensin-converting enzyme 2 / angiotensin 1– 7 axis. The administration of pineal methoxyindoles (melatonin, 5-methoxytryptamine), cannabinoids, and angiotensin 1– 7 may entail potential therapeutic benefits for NCDs, particularly for patients who do not respond to conventional treatments.Patients and Methods: This study evaluates the safety and efficacy of a neuroimmune regimen comprising melatonin (100 mg/day at night), 5-methoxytryptamine (30 mg in the early afternoon), angiotensin 1– 7 (0.5 mg twice daily), and cannabidiol (20 mg twice daily) in 306 patients with NCDs, including advanced cancer, autoimmune diseases, neurodegenerative disorders, depression, and cardiovascular disease.Results: The neuroimmune regimen successfully halted cancer progression in 68% of cancer patients, who also reported improvements in mood, sleep, and relief from anxiety, pain, and fatigue. In patients with autoimmune diseases, the treatment effectively controlled the disease process, remarkable in cases of multiple sclerosis. Additionally, positive outcomes were observed in patients with Parkinson’s disease, Alzheimer’s disease, and depression.Conclusion: Randomized controlled trials are required to assess this therapeutic approach for NCDs that includes endogenous neuroendocrine molecules regulating immune responses in an anti-inflammatory manner.Keywords: melatonin, 5-methoxytryptamine, metainflammation, noncommunicable diseases, oxytocin, pinoline

Keywords

• melatonin
• 5-methoxytryptamine
• metainflammation
• noncommunicable diseases
• oxytocin
• pinoline.