Two-Dimensional Homonuclear Orthogonal-Pattern Phase-Sensitive J-Resolved NMR Spectroscopy Based on Pure Shifts

Abstract

Two-dimensional J-resolved (2D JRES) nuclear magnetic resonance (NMR) experiments provide a simple and user-friendly spectral representation, in which J couplings and chemical shifts are separated into two orthogonal frequency dimensions. The 2D JRES experiments have attracted wide attention in fundamental pulse sequence developments and practical applications, since they were first proposed 40 years ago. In this paper, we review the recent advances in the development of novel 2D JRES pulse sequences and 2D J-edited methods for accurate measurements of J coupling, mainly focusing on pure shift based 2D orthogonal-pattern and phase-sensitive 2D JRES spectroscopy and their applications in overcoming strong coupling effects and field inhomogeneities.

Keywords

• nuclear magnetic resonance (nmr)
• j-resolved spectroscopy
• phase-sensitive
• g-serf
• j coupling constant
• pure shift