Local microRNA delivery targets Palladin and prevents metastatic breast cancer

Avital Gilam; João Conde; Daphna Weissglas-Volkov; Nuria Oliva; Eitan Friedman; Natalie Artzi; Noam Shomron

doi:10.1038/ncomms12868

Nature Communications (Sep 2016)

Local microRNA delivery targets Palladin and prevents metastatic breast cancer

Avital Gilam,
João Conde,
Daphna Weissglas-Volkov,
Nuria Oliva,
Eitan Friedman,
Natalie Artzi,
Noam Shomron

Affiliations

Avital Gilam: Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University
João Conde: Massachusetts Institute of Technology, Institute for Medical Engineering and Science
Daphna Weissglas-Volkov: Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University
Nuria Oliva: Massachusetts Institute of Technology, Institute for Medical Engineering and Science
Eitan Friedman: The Susanne Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center Tel-Hashomer
Natalie Artzi: Massachusetts Institute of Technology, Institute for Medical Engineering and Science
Noam Shomron: Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University

DOI: https://doi.org/10.1038/ncomms12868
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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MicroRNAs represent potential therapeutic targets to control metastasis progression. Here the authors show that miR-96 and miR-182 regulate invasion via Palladin and demonstrate that local delivery of miR-96 and miR-182 may serve as a potential anti-metastatic drug in breast cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal