Hsp90: From Cellular to Organismal Proteostasis

Milán Somogyvári; Saba Khatatneh; Csaba Sőti

doi:10.3390/cells11162479

Cells (Aug 2022)

Hsp90: From Cellular to Organismal Proteostasis

Milán Somogyvári,
Saba Khatatneh,
Csaba Sőti

Affiliations

Milán Somogyvári: Department of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary
Saba Khatatneh: Department of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary
Csaba Sőti: Department of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary

DOI: https://doi.org/10.3390/cells11162479
Journal volume & issue: Vol. 11, no. 16
p. 2479

Abstract

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Assuring a healthy proteome is indispensable for survival and organismal health. Proteome disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The essential molecular chaperone Hsp90 is a regulator of the heat shock response via HSF1 and a stabilizer of a plethora of signaling proteins. In this review, we summarize the role of Hsp90 in the cellular and organismal regulation of proteome maintenance.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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Abstract

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