Communications Biology (Jan 2021)

Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors

  • Tomohiko Matsuo,
  • Tomoko Isosaka,
  • Lijun Tang,
  • Tomoyoshi Soga,
  • Reiko Kobayakawa,
  • Ko Kobayakawa

DOI
https://doi.org/10.1038/s42003-020-01629-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

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Matsuo, Isosaka, et al report that innate fear, but not learned fear, in mice results in systemic hypothermia/hypometabolism and suppressed aerobic metabolism, which enables survival in hypoxic environments. They demonstrate that this process is orchestrated via the brain stem Sp5/NST to midbrain PBN pathway. This study provides insight into the relationship between innate fear and its intrinsic life protective abilities