Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Francois Moreau; Nicholas S. Kirk; Fa Zhang; Vasily Gelfanov; Edward O. List; Martina Chrudinová; Hari Venugopal; Michael C. Lawrence; Veronica Jimenez; Fatima Bosch; John J. Kopchick; Richard D. DiMarchi; Emrah Altindis; C. Ronald Kahn

doi:10.1038/s41467-022-34391-6

Nature Communications (Nov 2022)

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Francois Moreau,
Nicholas S. Kirk,
Fa Zhang,
Vasily Gelfanov,
Edward O. List,
Martina Chrudinová,
Hari Venugopal,
Michael C. Lawrence,
Veronica Jimenez,
Fatima Bosch,
John J. Kopchick,
Richard D. DiMarchi,
Emrah Altindis,
C. Ronald Kahn

Affiliations

Francois Moreau: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Nicholas S. Kirk: WEHI
Fa Zhang: Department of Chemistry, Indiana University
Vasily Gelfanov: Novo Nordisk, Indianapolis Research Center
Edward O. List: Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University
Martina Chrudinová: Boston College Biology Department
Hari Venugopal: Ramaciotti Centre for Cryo-Electron Microscopy, Monash University
Michael C. Lawrence: WEHI
Veronica Jimenez: Department of Biochemistry and Molecular Biology, School of Veterinary Medicine and Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona
Fatima Bosch: Department of Biochemistry and Molecular Biology, School of Veterinary Medicine and Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona
John J. Kopchick: Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University
Richard D. DiMarchi: Department of Chemistry, Indiana University
Emrah Altindis: Boston College Biology Department
C. Ronald Kahn: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-022-34391-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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The authors previously identified a family of viral insulin-like peptides (VILPs) with high homology to human insulin/IGF−1. Here, they report that one of these VILPs exhibits antagonist properties associated with a unique conformation of the IGF1R.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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