Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis

Rachana R. Chandran; Yi Xie; Eunate Gallardo-Vara; Taylor Adams; Rolando Garcia-Milian; Inamul Kabir; Abdul Q. Sheikh; Naftali Kaminski; Kathleen A. Martin; Erica L. Herzog; Daniel M. Greif

doi:10.1038/s41467-021-27499-8

Nature Communications (Dec 2021)

Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis

Rachana R. Chandran,
Yi Xie,
Eunate Gallardo-Vara,
Taylor Adams,
Rolando Garcia-Milian,
Inamul Kabir,
Abdul Q. Sheikh,
Naftali Kaminski,
Kathleen A. Martin,
Erica L. Herzog,
Daniel M. Greif

Affiliations

Rachana R. Chandran: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Yi Xie: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Eunate Gallardo-Vara: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Taylor Adams: Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine
Rolando Garcia-Milian: Bioinformatics Support Program, Yale University School of Medicine
Inamul Kabir: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Abdul Q. Sheikh: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Naftali Kaminski: Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine
Kathleen A. Martin: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Erica L. Herzog: Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine
Daniel M. Greif: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-27499-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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The pluripotency factor KLF4 has been described as pro-fibrotic or anti-fibrotic in various diseases. Herein, the authors show that during lung fibrosis, these distinct effects can be attributed to mesenchymal cell-type specific functions of KLF4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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