Acta Biomedica Scientifica (Apr 2013)
ROLE OF VIOLATIONS VEGETATIVE, ENERGY HOMEOSTASIS AND FATTY ACID COMPOSITION OF ERYTHROCYTE MEMBRANES IN HEART ARRHYTHMIAS IN PATIENTS WITH CHRONIC PROSTATITIS
Abstract
Aim. Studies on the role of autonomic disorders, changes of serum NEFA, glycerol, adenine nucleotides and violation fraction of the fatty acids of erythrocyte membranes in the development of cardiac arrhythmias in patients with chronic prostatitis. Methods. The study included 50 patients with chronic prostatitis, mean age 35 ± 5,6 years. Vegetative state is defined by: clinical evaluation of autonomic disorders, autonomic profiles and vegetative index Kerdo. Performed Holter ECG monitoring with analysis of heart rate variability. The blood was determined NEFA, glycerol, macroergs concentration and size distribution of higher fatty acids in red blood cells. Results. The majority of patients with chronic prostatitis on the questionnaire data revealed sympathotony manifested reduced the basic parameters of heart rate variability. In these patients have the syndrome disorders utilization of fatty acids, characterized by the accumulation in the blood NEFA while reducing the level of glycerol, and decreased ATP content in red blood cells and increased AMP. The greatest changes in the level and composition of free fatty acids in erythrocyte membranes as raising saturated and polyunsaturated reduction deal with chronic prostatitis with the activation of the sympathetic autonomous nervous system level. Among patients simpatotonikov often recorded supraventricular and ventricular arrhythmias, whereas patients-eytonik arrhythmias detected less frequently, and they are only a single supraventricular extrasystoles. Thus, long-term activation of the sympathetic nervous system in patients with chronic prostatitis, manifested by reduction of basic parameters of heart rate variability leads to a syndrome disorders utilization of fatty acids in the myocardium, the energy deficit and implement the lipolytic effect of catecholamines from the imbalance of the quality of the free fatty acids, which can be a trigger mechanism in the development of cardiac arrhythmias in these patients.
