Generation of an induced pluripotent stem cell (iPSC) line (EXSURGi001-A) from a patient homozygous for the p.Ala165Thr mutation in the MTARC1 gene

Peter Tang; Eriselda Keshi; Silvana Wilken; Louise Wutsdorff; Julienne Mougnekabol; Johann Pratschke; Igor M. Sauer; Nils Haep

Stem Cell Research (Oct 2024)

Generation of an induced pluripotent stem cell (iPSC) line (EXSURGi001-A) from a patient homozygous for the p.Ala165Thr mutation in the MTARC1 gene

Peter Tang,
Eriselda Keshi,
Silvana Wilken,
Louise Wutsdorff,
Julienne Mougnekabol,
Johann Pratschke,
Igor M. Sauer,
Nils Haep

Affiliations

Peter Tang: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Eriselda Keshi: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Clinician Scientist Program, Berlin Institute of Health at Charité (BIH), Anna-Louisa-Karsch-Str. 2, 10178 Berlin, Germany
Silvana Wilken: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Louise Wutsdorff: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Julienne Mougnekabol: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Johann Pratschke: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Igor M. Sauer: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Nils Haep: Department of Surgery, Campus Virchow-Klinikum, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Clinician Scientist Program, Berlin Institute of Health at Charité (BIH), Anna-Louisa-Karsch-Str. 2, 10178 Berlin, Germany; Corresponding author at: Department of Surgery, CCM|CVK, Experimental Surgery, Department of Surgery, CCM, Germany.

Journal volume & issue: Vol. 80
p. 103516

Abstract

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Metabolic dysfunction-associated fatty liver disease (MAFLD), the leading cause of end-stage liver disease in developed countries, is expected to increase over the next decade. Characterized by hepatic steatosis, MAFLD is commonly studied in animal models. Here, we generated a human induced pluripotent stem cell (iPSC) line from a patient homozygous of the protective MTARC1 gene variant rs2642438:A. This line displays a normal karyotype and typical pluripotent stem cell morphology and can differentiate into all three germ layers in vitro.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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