Nature Communications (Jul 2021)

M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

  • Indira Bag,
  • Shue Chen,
  • Leah F. Rosin,
  • Yang Chen,
  • Chen-Yu Liu,
  • Guo-Yun Yu,
  • Elissa P. Lei

DOI
https://doi.org/10.1038/s41467-021-24407-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.