A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent

Yin Chen; Peng Gao; Lu Huang; Xing Tan; Ningling Zhou; Tong Yang; Hua Qiu; Xin Dai; Sean Michael; Qiufen Tu; Nan Huang; Zhihong Guo; Jianhua Zhou; Zhilu Yang; Hongkai Wu

doi:10.1038/s41467-021-27368-4

Nature Communications (Dec 2021)

A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent

Yin Chen,
Peng Gao,
Lu Huang,
Xing Tan,
Ningling Zhou,
Tong Yang,
Hua Qiu,
Xin Dai,
Sean Michael,
Qiufen Tu,
Nan Huang,
Zhihong Guo,
Jianhua Zhou,
Zhilu Yang,
Hongkai Wu

Affiliations

Yin Chen: School of Biomedical Engineering, Sun Yat-sen University
Peng Gao: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Lu Huang: School of Biomedical Engineering, Sun Yat-sen University
Xing Tan: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Ningling Zhou: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Tong Yang: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Hua Qiu: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Xin Dai: Department of Chemistry, The Hong Kong University of Science and Technology
Sean Michael: Department of Chemistry, The Hong Kong University of Science and Technology
Qiufen Tu: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Nan Huang: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Zhihong Guo: Department of Chemistry, The Hong Kong University of Science and Technology
Jianhua Zhou: School of Biomedical Engineering, Sun Yat-sen University
Zhilu Yang: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University
Hongkai Wu: Department of Chemistry, The Hong Kong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-021-27368-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Neointimal hyperplasia and stent thrombosis remain issues with vascular stents. Here, the authors report on the development of a nitric oxide releasing hydrogel which allows for endothelialisation of the stent surface and prevents smooth muscle cell growth reducing hyperplasia and thrombosis in in vivo models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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