Nature Communications (Oct 2020)
Targeting N-myristoylation for therapy of B-cell lymphomas
- Erwan Beauchamp,
- Megan C. Yap,
- Aishwarya Iyer,
- Maneka A. Perinpanayagam,
- Jay M. Gamma,
- Krista M. Vincent,
- Manikandan Lakshmanan,
- Anandhkumar Raju,
- Vinay Tergaonkar,
- Soo Yong Tan,
- Soon Thye Lim,
- Wei-Feng Dong,
- Lynne M. Postovit,
- Kevin D. Read,
- David W. Gray,
- Paul G. Wyatt,
- John R. Mackey,
- Luc G. Berthiaume
Affiliations
- Erwan Beauchamp
- Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta
- Megan C. Yap
- Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta
- Aishwarya Iyer
- Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta
- Maneka A. Perinpanayagam
- Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta
- Jay M. Gamma
- Departments of Medicine, Faculty of Medicine and Dentistry, University of Alberta
- Krista M. Vincent
- Departments of Oncology, Faculty of Medicine and Dentistry, University of Alberta
- Manikandan Lakshmanan
- Mouse Models of Human Cancer Unit, Institute of Molecular and Cell Biology
- Anandhkumar Raju
- Advanced Molecular Pathology Lab, Institute of Molecular and Cell Biology
- Vinay Tergaonkar
- Advanced Molecular Pathology Lab, Institute of Molecular and Cell Biology
- Soo Yong Tan
- Advanced Molecular Pathology Lab, Institute of Molecular and Cell Biology
- Soon Thye Lim
- Department of Medical Oncology, National Cancer Centre Singapore
- Wei-Feng Dong
- Departments of Oncology, Faculty of Medicine and Dentistry, University of Alberta
- Lynne M. Postovit
- Departments of Oncology, Faculty of Medicine and Dentistry, University of Alberta
- Kevin D. Read
- Drug Discovery Unit, School of Life Sciences, University of Dundee, James Black Centre
- David W. Gray
- Drug Discovery Unit, School of Life Sciences, University of Dundee, James Black Centre
- Paul G. Wyatt
- Drug Discovery Unit, School of Life Sciences, University of Dundee, James Black Centre
- John R. Mackey
- Pacylex Pharmaceuticals Inc.
- Luc G. Berthiaume
- Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta
- DOI
- https://doi.org/10.1038/s41467-020-18998-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatment strategy for lymphoma patients.
