Safety profile assessment of HPV4 and HPV9 vaccines through the passive surveillance system of the Veneto Region (Italy) between 2008 and 2022: A 15-year retrospective observational study
Diana Dalla Valle,
Roberto Benoni,
Nicola Soriolo,
Chiara Battistella,
Francesca Moretti,
Laura Augusta Gonella,
Stefano Tardivo,
Silvia Colpo,
Sara Montresor,
Francesca Russo,
Michele Tonon,
Filippo Da Re,
Ugo Moretti,
Giovanna Zanoni
Affiliations
Diana Dalla Valle
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy
Roberto Benoni
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy; Corresponding author at: Department of Diagnostics and Public Health, University of Verona, Strada Le Grazie, 8 – 37134 Verona, Italy.
Nicola Soriolo
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy
Chiara Battistella
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy
Francesca Moretti
University of Verona, Neurosciences, Biomedicine and Movement Sciences Department, Verona, Italy
Laura Augusta Gonella
University of Verona, Diagnostics and Public Health Department, Section of Pharmacology, Verona, Italy
Stefano Tardivo
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy
Silvia Colpo
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy
Sara Montresor
University of Verona, Diagnostics and Public Health Department, Section of Hygiene and Preventive Medicine, Verona, Italy
Francesca Russo
Directorate of Prevention, Food Safety, Veterinary Public Health, Veneto Region, Venice, Italy
Michele Tonon
Directorate of Prevention, Food Safety, Veterinary Public Health, Veneto Region, Venice, Italy
Filippo Da Re
Directorate of Prevention, Food Safety, Veterinary Public Health, Veneto Region, Venice, Italy
Ugo Moretti
University of Verona, Diagnostics and Public Health Department, Section of Pharmacology, Verona, Italy
Giovanna Zanoni
University Hospital of Verona, Pathology and Diagnostics Department, Immunology Unit, Verona, Italy
In Veneto Region, HPV vaccine has been actively offered to 12 year-old females since 2008, and to 12 year-old males since 2015. The study aims to analyze the safety profile of HPV4v and HPV9v vaccines and perform a case-by-case review of conditions of interest.Spontaneous reports related to HPV uploaded to the database of the Regional Pharmacovigilance Center between 2008–2022 were included. HPV vaccine doses administered until April 2022 in the Veneto Region were considered to calculate the reporting rate (RR).Potential “safety concerns” examined as conditions of interest were included through Standardized MedDRA or preferred terms searching queries. The level of diagnostic certainty was evaluated as per the Brighton Collaboration case definition criteria.A total of 637 reports and 1316 Adverse Events Following Immunizations (AEFI) were retrieved: 469 for HPV4v (73.6 %) and 168 for HPV9v (26.4 %). Serious reports were 71 (11.1 %): 49 (10.4 %) for HPV4v and 22 (13.1 %) for HPV9v. The RR for serious events between 2008–2022 was 6.9/100,000 administered doses, with no differences by vaccine type. Females and adults showed higher overall RR compared to males and to children and adolescents (p < 0.001), this result was confirmed by stratifying analysis by vaccine type. One case of Guillain Barré syndrome, anaphylactic shock, thrombocytopenia, Henoch Schoenlein purpura and four generalized seizures were reviewed.Vaccinovigilance data from the Veneto Region reaffirm a good safety profile for HPV vaccination and found no vaccine-related unexpected events. Such a detailed analysis may assist healthcare providers to advocate properly for HPV vaccination.
