Nature Communications (Feb 2021)
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
- Jing Zhao,
- Alan Blayney,
- Xiaorong Liu,
- Lauren Gandy,
- Weihua Jin,
- Lufeng Yan,
- Jeung-Hoi Ha,
- Ashley J. Canning,
- Michael Connelly,
- Chao Yang,
- Xinyue Liu,
- Yuanyuan Xiao,
- Michael S. Cosgrove,
- Sozanne R. Solmaz,
- Yingkai Zhang,
- David Ban,
- Jianhan Chen,
- Stewart N. Loh,
- Chunyu Wang
Affiliations
- Jing Zhao
- College of Food Science and Nutritional Engineering, China Agricultural University
- Alan Blayney
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University
- Xiaorong Liu
- Department of Chemistry, University of Massachusetts
- Lauren Gandy
- Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute
- Weihua Jin
- Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute
- Lufeng Yan
- Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute
- Jeung-Hoi Ha
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University
- Ashley J. Canning
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University
- Michael Connelly
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University
- Chao Yang
- Department of Chemistry, New York University
- Xinyue Liu
- Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute
- Yuanyuan Xiao
- Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute
- Michael S. Cosgrove
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University
- Sozanne R. Solmaz
- Department of Chemistry, State University of New York at Binghamton
- Yingkai Zhang
- Department of Chemistry, New York University
- David Ban
- Merck Research Laboratories, Mass Spectrometry and Biophysics
- Jianhan Chen
- Department of Chemistry, University of Massachusetts
- Stewart N. Loh
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University
- Chunyu Wang
- Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute
- DOI
- https://doi.org/10.1038/s41467-021-21258-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Epigallocatechin gallate (EGCG) is a catechin flavonoid which induces apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Here authors use an interdisciplinary approach to show a direct interaction between EGCG and the tumor suppressor p53 and demonstrate that EGCG inhibits ubiquitination of p53 by MDM2.
