Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy

• Lei Yu,
• Pengcheng Zhao,
• Yaoliang Sun,
• Zening Zheng,
• Wenhao Du,
• Lishan Zhang,
• Yaxu Li,
• Longyan Xie,
• Shilin Xu,
• Ping Wang

Affiliations

Lei Yu

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

Pengcheng Zhao

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

Yaoliang Sun

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Zening Zheng

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

Wenhao Du

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Lishan Zhang

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Yaxu Li

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

Longyan Xie

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

Shilin Xu

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Ping Wang

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University