Frontiers in Public Health (Jun 2022)
The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand
- Supinda Koonmee,
- Supinda Koonmee,
- Supinda Koonmee,
- Sakkarn Sangkhamanon,
- Sakkarn Sangkhamanon,
- Sakkarn Sangkhamanon,
- Piyapharom Intarawichian,
- Piyapharom Intarawichian,
- Piyapharom Intarawichian,
- Chaiwat Aphivatanasiri,
- Chaiwat Aphivatanasiri,
- Chaiwat Aphivatanasiri,
- Waritta Kunprom,
- Waritta Kunprom,
- Waritta Kunprom,
- Prakasit Sa-ngiamwibool,
- Prakasit Sa-ngiamwibool,
- Prakasit Sa-ngiamwibool,
- Suwit Balthaisong,
- Suwit Balthaisong,
- Suwit Balthaisong,
- Chitsakul Phuyao,
- Chitsakul Phuyao,
- Chitsakul Phuyao,
- Piya Prajumwongs,
- Piya Prajumwongs,
- Piya Prajumwongs,
- Reza Alaghehbandan,
- Malinee Thanee,
- Malinee Thanee,
- Malinee Thanee
Affiliations
- Supinda Koonmee
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Supinda Koonmee
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Supinda Koonmee
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Sakkarn Sangkhamanon
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Sakkarn Sangkhamanon
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Sakkarn Sangkhamanon
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Piyapharom Intarawichian
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Piyapharom Intarawichian
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Piyapharom Intarawichian
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Chaiwat Aphivatanasiri
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Chaiwat Aphivatanasiri
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Chaiwat Aphivatanasiri
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Waritta Kunprom
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Waritta Kunprom
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Waritta Kunprom
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Prakasit Sa-ngiamwibool
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Prakasit Sa-ngiamwibool
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Prakasit Sa-ngiamwibool
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Suwit Balthaisong
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Suwit Balthaisong
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Suwit Balthaisong
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Chitsakul Phuyao
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Chitsakul Phuyao
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Chitsakul Phuyao
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Piya Prajumwongs
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Piya Prajumwongs
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Piya Prajumwongs
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Reza Alaghehbandan
- Department of Pathology, Faculty of Medicine, Royal Columbian Hospital, University of British Columbia, Vancouver, BC, Canada
- Malinee Thanee
- Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand
- Malinee Thanee
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Malinee Thanee
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- DOI
- https://doi.org/10.3389/fpubh.2022.792847
- Journal volume & issue
-
Vol. 10
Abstract
Cholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and preservation during the pre-analytical phase play major roles in the proper histological evaluation and potential biomarker testing. This study evaluated the impact of using the “Cholangiocarcinoma Screening and Care Program (CASCAP)” container, as an innovative tool to address pre-analytical challenges faced by pathology laboratories in Thailand. This is a comparison study examining the quality of CCA specimens using the CASCAP container vs. the conventional method, using hematoxylin and eosin (H&E) and immunohistochemistry (IHC). CCA tissue quality using the CASCAP container significantly reduced artifact deposition while improving the cellular structure and nuclear and cytoplasmic morphologies. The immunohistochemical expression of cytokeratin 19 (CK19), a prognostic marker in CCA, significantly improved in the CASCAP container group in comparison with the conventional method. This innovation is proven to significantly enhance the CCA tissue quality diagnostics and prognostic biomarker testing, hence improving overall cancer care, diagnosis, and treatment in Thailand.
Keywords