Nature Communications (Nov 2022)

High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers

  • Ruochen Ouyang,
  • Ana Rita Costa,
  • C. Keith Cassidy,
  • Aleksandra Otwinowska,
  • Vera C. J. Williams,
  • Agnieszka Latka,
  • Phill J. Stansfeld,
  • Zuzanna Drulis-Kawa,
  • Yves Briers,
  • Daniël M. Pelt,
  • Stan J. J. Brouns,
  • Ariane Briegel

DOI
https://doi.org/10.1038/s41467-022-34972-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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The jumbo contractile bacteriophage, Kp24, has been isolated from clinical strains of Klebsiella pneumonia. Here, the authors present structural and functional insight into the capsid, tail and tail fibres and how this impacts infectivity.