Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

Abstract

Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the '' Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway'' network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.

Keywords

• Public antidote wasolytic wash
• Network pharmacology
• Diabetic foot ulcers
• Molecular mechanism
• External treatment of traditional chinese medicine