Nature Communications (Apr 2022)
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
- Anne-Katrin Rohlfing,
- Kyra Kolb,
- Manuel Sigle,
- Melanie Ziegler,
- Alexander Bild,
- Patrick Münzer,
- Jessica Sudmann,
- Valerie Dicenta,
- Tobias Harm,
- Mailin-Christin Manke,
- Sascha Geue,
- Marcel Kremser,
- Madhumita Chatterjee,
- Chunguang Liang,
- Hendrik von Eysmondt,
- Thomas Dandekar,
- David Heinzmann,
- Manina Günter,
- Saskia von Ungern-Sternberg,
- Manuela Büttcher,
- Tatsiana Castor,
- Stine Mencl,
- Friederike Langhauser,
- Katharina Sies,
- Diyaa Ashour,
- Mustafa Caglar Beker,
- Michael Lämmerhofer,
- Stella E. Autenrieth,
- Tilman E. Schäffer,
- Stefan Laufer,
- Paulina Szklanna,
- Patricia Maguire,
- Matthias Heikenwalder,
- Karin Anne Lydia Müller,
- Dirk M. Hermann,
- Ertugrul Kilic,
- Ralf Stumm,
- Gustavo Ramos,
- Christoph Kleinschnitz,
- Oliver Borst,
- Harald F. Langer,
- Dominik Rath,
- Meinrad Gawaz
Affiliations
- Anne-Katrin Rohlfing
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Kyra Kolb
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Manuel Sigle
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Melanie Ziegler
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Alexander Bild
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Patrick Münzer
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Jessica Sudmann
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Valerie Dicenta
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Tobias Harm
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Mailin-Christin Manke
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Sascha Geue
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Marcel Kremser
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Madhumita Chatterjee
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Chunguang Liang
- Department of Bioinformatics, Biocenter, University of Würzburg
- Hendrik von Eysmondt
- Institute of Applied Physics, University of Tübingen
- Thomas Dandekar
- Department of Bioinformatics, Biocenter, University of Würzburg
- David Heinzmann
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Manina Günter
- Department of Dendritic Cells in Infection and Cancer, German Cancer Research Centre
- Saskia von Ungern-Sternberg
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Manuela Büttcher
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Tatsiana Castor
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Stine Mencl
- Department of Neurology, University Hospital Essen
- Friederike Langhauser
- Department of Neurology, University Hospital Essen
- Katharina Sies
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ)
- Diyaa Ashour
- Immunocardiology Lab, University Hospital Würzburg, Comprehensive Heart Failure Center (CHFC)
- Mustafa Caglar Beker
- Department of Physiology, School of Medicine, Istanbul Medipol University
- Michael Lämmerhofer
- University of Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis
- Stella E. Autenrieth
- Department of Dendritic Cells in Infection and Cancer, German Cancer Research Centre
- Tilman E. Schäffer
- Institute of Applied Physics, University of Tübingen
- Stefan Laufer
- Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University of Tübingen
- Paulina Szklanna
- Conway-SPHERE Research Group, Conway Institute, University College Dublin
- Patricia Maguire
- Conway-SPHERE Research Group, Conway Institute, University College Dublin
- Matthias Heikenwalder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ)
- Karin Anne Lydia Müller
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Dirk M. Hermann
- Vascular Neurology, Dementia and Ageing Research, Department of Neurology
- Ertugrul Kilic
- Department of Physiology, School of Medicine, Istanbul Medipol University
- Ralf Stumm
- Institute of Pharmacology and Toxicology, Jena University Hospital
- Gustavo Ramos
- Immunocardiology Lab, University Hospital Würzburg, Comprehensive Heart Failure Center (CHFC)
- Christoph Kleinschnitz
- Department of Neurology, University Hospital Essen
- Oliver Borst
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Harald F. Langer
- University Hospital, Medical Clinic II, University Heart Center
- Dominik Rath
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- Meinrad Gawaz
- Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen
- DOI
- https://doi.org/10.1038/s41467-022-29341-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
