Nature Communications (Feb 2020)

Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus

  • Kyoung-Dong Kim,
  • Hideki Tanizawa,
  • Alessandra De Leo,
  • Olga Vladimirova,
  • Andrew Kossenkov,
  • Fang Lu,
  • Louise C. Showe,
  • Ken-ichi Noma,
  • Paul M. Lieberman

DOI
https://doi.org/10.1038/s41467-019-14152-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced genes in Burkitt lymphoma cells.