Nature Communications (Jan 2020)
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
- Linda Kachuri,
- Mattias Johansson,
- Sara R. Rashkin,
- Rebecca E. Graff,
- Yohan Bossé,
- Venkata Manem,
- Neil E. Caporaso,
- Maria Teresa Landi,
- David C. Christiani,
- Paolo Vineis,
- Geoffrey Liu,
- Ghislaine Scelo,
- David Zaridze,
- Sanjay S. Shete,
- Demetrius Albanes,
- Melinda C. Aldrich,
- Adonina Tardón,
- Gad Rennert,
- Chu Chen,
- Gary E. Goodman,
- Jennifer A. Doherty,
- Heike Bickeböller,
- John K. Field,
- Michael P. Davies,
- M. Dawn Teare,
- Lambertus A. Kiemeney,
- Stig E. Bojesen,
- Aage Haugen,
- Shanbeh Zienolddiny,
- Stephen Lam,
- Loïc Le Marchand,
- Iona Cheng,
- Matthew B. Schabath,
- Eric J. Duell,
- Angeline S. Andrew,
- Jonas Manjer,
- Philip Lazarus,
- Susanne Arnold,
- James D. McKay,
- Nima C. Emami,
- Matthew T. Warkentin,
- Yonathan Brhane,
- Ma’en Obeidat,
- Richard M. Martin,
- Caroline Relton,
- George Davey Smith,
- Philip C. Haycock,
- Christopher I. Amos,
- Paul Brennan,
- John S. Witte,
- Rayjean J. Hung
Affiliations
- Linda Kachuri
- Department of Epidemiology & Biostatistics, University of California San Francisco
- Mattias Johansson
- International Agency for Research on Cancer
- Sara R. Rashkin
- Department of Epidemiology & Biostatistics, University of California San Francisco
- Rebecca E. Graff
- Department of Epidemiology & Biostatistics, University of California San Francisco
- Yohan Bossé
- Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval
- Venkata Manem
- Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval
- Neil E. Caporaso
- Division of Cancer Epidemiology & Genetics, US NCI
- Maria Teresa Landi
- Division of Cancer Epidemiology & Genetics, US NCI
- David C. Christiani
- Departments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health
- Paolo Vineis
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Geoffrey Liu
- Princess Margaret Cancer Center, University Health Network
- Ghislaine Scelo
- International Agency for Research on Cancer
- David Zaridze
- Russian N.N. Blokhin Cancer Research Centre
- Sanjay S. Shete
- Department of Biostatistics, Division of Basic Sciences, MD Anderson Cancer Center
- Demetrius Albanes
- Division of Cancer Epidemiology & Genetics, US NCI
- Melinda C. Aldrich
- Department of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center
- Adonina Tardón
- Faculty of Medicine, University of Oviedo and ISPA and CIBERESP, Campus del Cristo
- Gad Rennert
- Clalit National Cancer Control Center, Technion Faculty of Medicine
- Chu Chen
- Fred Hutchinson Cancer Research Center
- Gary E. Goodman
- Fred Hutchinson Cancer Research Center
- Jennifer A. Doherty
- Department of Population Health Sciences, Huntsman Cancer Institute
- Heike Bickeböller
- Department of Genetic Epidemiology, University Medical Center, Georg-August-Universität Göttingen
- John K. Field
- Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool
- Michael P. Davies
- Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool
- M. Dawn Teare
- Biostatistics Research Group, Institute of Health and Society, Newcastle University
- Lambertus A. Kiemeney
- Radboud Institute for Health Sciences, Radboud University Medical Centre
- Stig E. Bojesen
- Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Aage Haugen
- The National Institute of Occupational Health
- Shanbeh Zienolddiny
- The National Institute of Occupational Health
- Stephen Lam
- BC Cancer Agency
- Loïc Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Iona Cheng
- Department of Epidemiology & Biostatistics, University of California San Francisco
- Matthew B. Schabath
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute
- Eric J. Duell
- Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL)
- Angeline S. Andrew
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College
- Jonas Manjer
- Skåne University Hospital, Lund University
- Philip Lazarus
- Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University
- Susanne Arnold
- Markey Cancer Center, University of Kentucky
- James D. McKay
- International Agency for Research on Cancer
- Nima C. Emami
- Department of Epidemiology & Biostatistics, University of California San Francisco
- Matthew T. Warkentin
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Yonathan Brhane
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Ma’en Obeidat
- University of British Columbia, Centre for Heart Lung Innovation
- Richard M. Martin
- MRC Integrative Epidemiology Unit, University of Bristol
- Caroline Relton
- MRC Integrative Epidemiology Unit, University of Bristol
- George Davey Smith
- MRC Integrative Epidemiology Unit, University of Bristol
- Philip C. Haycock
- MRC Integrative Epidemiology Unit, University of Bristol
- Christopher I. Amos
- Institute for Clinical and Translational Research, Baylor College of Medicine
- Paul Brennan
- International Agency for Research on Cancer
- John S. Witte
- Department of Epidemiology & Biostatistics, University of California San Francisco
- Rayjean J. Hung
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- DOI
- https://doi.org/10.1038/s41467-019-13855-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathways
