Nature Communications (Aug 2018)
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin
- Florian Haun,
- Simon Neumann,
- Lukas Peintner,
- Katrin Wieland,
- Jüri Habicht,
- Carsten Schwan,
- Kristine Østevold,
- Maria Magdalena Koczorowska,
- Martin Biniossek,
- Matthias Kist,
- Hauke Busch,
- Melanie Boerries,
- Roger J. Davis,
- Ulrich Maurer,
- Oliver Schilling,
- Klaus Aktories,
- Christoph Borner
Affiliations
- Florian Haun
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Simon Neumann
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Lukas Peintner
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Katrin Wieland
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Jüri Habicht
- Institute of Immunology, University Hospital Heidelberg
- Carsten Schwan
- Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University Freiburg
- Kristine Østevold
- Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University Freiburg
- Maria Magdalena Koczorowska
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Martin Biniossek
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Matthias Kist
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Hauke Busch
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Melanie Boerries
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Roger J. Davis
- Howard Hughes Medical Institute & Program in Molecular Medicine, University of Massachusetts Medical School
- Ulrich Maurer
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Oliver Schilling
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- Klaus Aktories
- Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg
- Christoph Borner
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert Ludwigs University Freiburg
- DOI
- https://doi.org/10.1038/s41467-018-05850-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK signalling leading to Bim-mediated anoikis.
