Utilizing panels of patient derived xenografts to aid the development of antibody drug conjugates

Abstract

Despite numerous endeavors in clinical trials there are few clinically approved Antibody Drug Conjugate (ADC) therapies. Here we comment on our recent publication demonstrating the power of using panels of patient-derived xenografts (PDX) prior to Phase 1, to assess the potential heterogeneity of response a clinical candidate may show across a population. Furthermore we discuss how the same approach has been used in an additional ADC program.

Keywords

• adc
• antibody drug conjugate
• cdh6
• hkt288
• patient-derived xenograft
• pct