Hypertension in Pregnancy (Jan 2017)

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

  • Carolien N. H. Abheiden,
  • Birgit S. Blomjous,
  • Sylvia J. Kroese,
  • Irene E. M. Bultink,
  • Ruth D. E. Fritsch-Stork,
  • A. Titia Lely,
  • Marjon A. de Boer,
  • Johanna I. P. de Vries

DOI
https://doi.org/10.1080/10641955.2016.1217337
Journal volume & issue
Vol. 36, no. 1
pp. 8 – 15

Abstract

Read online

Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

Keywords