Nature Communications (Feb 2021)
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
- Peng Gao,
- Xianwei Ma,
- Ming Yuan,
- Yulan Yi,
- Guoke Liu,
- Mingyue Wen,
- Wei Jiang,
- Ruihua Ji,
- Lingxi Zhu,
- Zhen Tang,
- Qingzhuo Yu,
- Jing Xu,
- Rui Yang,
- Sheng Xia,
- Mingjin Yang,
- Jianping Pan,
- Hongbin Yuan,
- Huazhang An
Affiliations
- Peng Gao
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Xianwei Ma
- Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University
- Ming Yuan
- Immunology Department & National Key Laboratory of Medical Immunology, Second Military Medical University
- Yulan Yi
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Guoke Liu
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Mingyue Wen
- Immunology Department & National Key Laboratory of Medical Immunology, Second Military Medical University
- Wei Jiang
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Ruihua Ji
- Department of Anesthesiology, Changzheng Hospital, Second Military Medical University
- Lingxi Zhu
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Zhen Tang
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Qingzhuo Yu
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Jing Xu
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- Rui Yang
- Department of Anesthesiology, Changzheng Hospital, Second Military Medical University
- Sheng Xia
- Department of Immunology, School of Medicine, Jiangsu University
- Mingjin Yang
- Immunology Department & National Key Laboratory of Medical Immunology, Second Military Medical University
- Jianping Pan
- Department of Clinical Medicine, Zhejiang University City College School of Medicine
- Hongbin Yuan
- Department of Anesthesiology, Changzheng Hospital, Second Military Medical University
- Huazhang An
- Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
- DOI
- https://doi.org/10.1038/s41467-021-21456-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Ubiquitination is a prevalent post translational modification. Here, the authors show a pivotal role for Nedd4l in the regulation of antiviral immunity via promotion of ubiquitination of TRAF3 and go on to show disruption of Nedd4l both in vitro and in vivo perturbs the antiviral immune response.
