Molecules (Aug 2021)

Nanoemulsification Improves the Pharmaceutical Properties and Bioactivities of Niaouli Essential Oil (<i>Melaleuca quinquenervia</i> L.)

  • Faiyaz Shakeel,
  • Mounir M. Salem-Bekhit,
  • Nazrul Haq,
  • Sultan Alshehri

DOI
https://doi.org/10.3390/molecules26164750
Journal volume & issue
Vol. 26, no. 16
p. 4750

Abstract

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We develop a suitable delivery system for niaouli essential oil (NEO) using a nanoemulsification method for acne vulgaris. Prepared nanoemulsions (NEs) were characterized for droplet dimension, rheology, surface charge, and stability. The ability of NEO formulations against Propionibacterium acnes and Staphylococcus epidermidis was investigated and all formulations showed antiacne potential in vitro. Ex vivo permeation studies indicated significant improvement in drug permeations and steady state flux of all NEO-NEs compared to the neat NEO (p 4 was found to be the best (oil (NEO; 10% v/v); Kolliphor EL (9.25% v/v), Carbitol (27.75% v/v), and water (53% v/v)). Concisely, the in vitro and ex vivo results revealed that nanoemulsification improved the delivery as well as bioactivities of NEO significantly.

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