Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

Wei Wen Teo; Xinang Cao; Chan-Shuo Wu; Hong Kee Tan; Qiling Zhou; Chong Gao; Kim Vanuytsel; Sara S. Kumar; George J. Murphy; Henry Yang; Li Chai; Daniel G. Tenen

doi:10.1038/s42003-022-03250-x

Communications Biology (Apr 2022)

Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

Wei Wen Teo,
Xinang Cao,
Chan-Shuo Wu,
Hong Kee Tan,
Qiling Zhou,
Chong Gao,
Kim Vanuytsel,
Sara S. Kumar,
George J. Murphy,
Henry Yang,
Li Chai,
Daniel G. Tenen

Affiliations

Wei Wen Teo: Cancer Science Institute of Singapore, National University of Singapore
Xinang Cao: Cancer Science Institute of Singapore, National University of Singapore
Chan-Shuo Wu: Cancer Science Institute of Singapore, National University of Singapore
Hong Kee Tan: Cancer Science Institute of Singapore, National University of Singapore
Qiling Zhou: Cancer Science Institute of Singapore, National University of Singapore
Chong Gao: Department of Pathology, Brigham and Women’s Hospital
Kim Vanuytsel: Section of Hematology and Medical Oncology, School of Medicine, Boston University
Sara S. Kumar: Section of Hematology and Medical Oncology, School of Medicine, Boston University
George J. Murphy: Section of Hematology and Medical Oncology, School of Medicine, Boston University
Henry Yang: Cancer Science Institute of Singapore, National University of Singapore
Li Chai: Department of Pathology, Brigham and Women’s Hospital
Daniel G. Tenen: Cancer Science Institute of Singapore, National University of Singapore

DOI: https://doi.org/10.1038/s42003-022-03250-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

Identification of a long non-coding RNA LEVER, that inhibits the Polycomb Repressive Complex 2 (PRC2) and controls nearby embryonic form of beta-globin gene, provides additional evidence for PRC2-RNA functional interaction.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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