Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts

Milan D. Valyear; Iulia Glovaci; Audrey Zaari; Soraya Lahlou; Ivan Trujillo-Pisanty; C. Andrew Chapman; Nadia Chaudhri

doi:10.1038/s41467-020-17543-4

Nature Communications (Jul 2020)

Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts

Milan D. Valyear,
Iulia Glovaci,
Audrey Zaari,
Soraya Lahlou,
Ivan Trujillo-Pisanty,
C. Andrew Chapman,
Nadia Chaudhri

Affiliations

Milan D. Valyear: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Iulia Glovaci: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Audrey Zaari: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Soraya Lahlou: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Ivan Trujillo-Pisanty: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
C. Andrew Chapman: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Nadia Chaudhri: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University

DOI: https://doi.org/10.1038/s41467-020-17543-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Alcohol craving can be enhanced by alcohol-associated cues and by alcohol-associated contexts. Here the authors investigate the role of the ventral tegmental area (VTA)-to-nucleus accumbens (NAc) core and VTA-to-NAc shell circuits in mediating these distinct aspects of alcohol seeking behaviour in rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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