Cross-talk between cancer and Pseudomonas aeruginosa mediates tumor suppression

Juliana K. Choi; Samer A. Naffouje; Masahide Goto; Jing Wang; Konstantin Christov; David J. Rademacher; Albert Green; Arlene A. Stecenko; Ananda M. Chakrabarty; Tapas K. Das Gupta; Tohru Yamada

doi:10.1038/s42003-022-04395-5

Communications Biology (Jan 2023)

Cross-talk between cancer and Pseudomonas aeruginosa mediates tumor suppression

Juliana K. Choi,
Samer A. Naffouje,
Masahide Goto,
Jing Wang,
Konstantin Christov,
David J. Rademacher,
Albert Green,
Arlene A. Stecenko,
Ananda M. Chakrabarty,
Tapas K. Das Gupta,
Tohru Yamada

Affiliations

Juliana K. Choi: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine
Samer A. Naffouje: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine
Masahide Goto: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine
Jing Wang: Department of Mathematics, Statistics and Computer Science, University of Illinois College of Liberal Arts and Sciences
Konstantin Christov: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine
David J. Rademacher: Department of Microbiology and Immunology and Core Imaging Facility, Loyola University Chicago
Albert Green: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine
Arlene A. Stecenko: Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine
Ananda M. Chakrabarty: Department of Microbiology & Immunology, University of Illinois College of Medicine
Tapas K. Das Gupta: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine
Tohru Yamada: Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine

DOI: https://doi.org/10.1038/s42003-022-04395-5
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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A bidirectional interaction between Pseudomonas aeruginosa (PA) bacteria and cancerous tumors results in an anti-tumor effect; cancer cells stimulate PA-secretion of azurin which promotes tumor cell production of aldolase A.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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