The Activation of cGAS-STING in Acute Kidney Injury

Abstract

Chuanchuan Sun,1 Heng Shi,1 Xinhai Zhao,2 Yu-Ling Chang,2 Xianghong Wang,3 Shiping Zhu,2 Shengyun Sun1 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 2Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 3Department of Endocrinology and Metabolism, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, People’s Republic of ChinaCorrespondence: Shengyun Sun, Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510630, People’s Republic of China, Email [email protected]: The activation of the cGAS-STING pathway is associated with many sterile inflammatory and inflammatory conditions, including acute kidney injury. As a cytoplasmic DNA sensor, sensitization of the cGAS-STING pathway can ignite the innate immune response in vivo and trigger a series of biological effects. In recent years, there is increasing evidence showing that the cGAS-STING pathway plays a vital role in acute kidney injury, a non-inflammatory disease induced by activation of innate immune cells, and closely related to intracellular reactive oxygen species, mitochondrial DNA, and the cGAS-STING pathway. This review provides a prospect of the cGAS-STING pathway and its relationship to acute kidney injury.Keywords: mitochondrial DNA, innate immunity, reactive oxygen species, mitochondrial dysfunction, acute kidney injury

Keywords

• mitochondrial dna
• innate immunity
• reactive oxygen species
• mitochondrial dysfunction
• acute kidney injury