The impact of hepatitis B virus (HBV) splicing on HBV replication and disease progression

Laura C. McCoullough; Margaret Littlejohn; Peter A. Revill

doi:10.37349/edd.2024.00054

Exploration of Digestive Diseases (Aug 2024)

The impact of hepatitis B virus (HBV) splicing on HBV replication and disease progression

Laura C. McCoullough,
Margaret Littlejohn,
Peter A. Revill

Affiliations

Laura C. McCoullough: ORCiD; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia
Margaret Littlejohn: ORCiD; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia
Peter A. Revill: ORCiD; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia

DOI: https://doi.org/10.37349/edd.2024.00054
Journal volume & issue: Vol. 3, no. 4
pp. 326 – 343

Abstract

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Chronic hepatitis B (CHB) disease caused by persistent infection with hepatitis B virus (HBV) is a global health problem affecting almost 300 million people worldwide, resulting in up to 1 million deaths each year. The factors contributing to HBV mediated liver disease are yet to be fully resolved, however, multiple studies have suggested that HBV splice variants may be a contributing factor. Recent studies have indicated that novel fusion proteins encoded by splice variants, or the splice-derived RNA itself, may impact replication of wild-type HBV, although the direct mechanisms for these interactions are largely unknown. This review explores the latest knowledge regarding the contribution of splice variants to liver disease and their impact on HBV replication.

Published in Exploration of Digestive Diseases

ISSN: 2833-6321 (Online)
Publisher: Open Exploration Publishing Inc.
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.explorationpub.com/Journals/edd

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