Synthesis and cytotoxicity studies of novel N-arylbenzo[h]quinazolin-2-amines

Abstract

In this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.

Keywords

• buchwald–hartwig coupling
• cytotoxicity
• heterocycles
• pd catalysis
• quinazolines