Nature Communications (Jun 2021)

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

  • Yun C. Chang,
  • Ami Khanal Lamichhane,
  • Hongyi Cai,
  • Peter J. Walter,
  • John E. Bennett,
  • Kyung J. Kwon-Chung

DOI
https://doi.org/10.1038/s41467-021-23745-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Pathogenic fungi rapidly develop resistance to the antifungal agent 5-fluorocytosine (5-FC). Here, Chang et al. explore the mechanisms by which Cryptococcus develops 5-FC resistance at a high frequency, including mutations in several genes and altered levels of key metabolites.