Nature Communications (Jun 2021)
Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
Abstract
Pathogenic fungi rapidly develop resistance to the antifungal agent 5-fluorocytosine (5-FC). Here, Chang et al. explore the mechanisms by which Cryptococcus develops 5-FC resistance at a high frequency, including mutations in several genes and altered levels of key metabolites.