Nature Communications (Oct 2016)

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

  • Anirban Chakraborty,
  • Nisha Tapryal,
  • Tatiana Venkova,
  • Nobuo Horikoshi,
  • Raj K. Pandita,
  • Altaf H. Sarker,
  • Partha S. Sarkar,
  • Tej K. Pandita,
  • Tapas K. Hazra

DOI
https://doi.org/10.1038/ncomms13049
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.