mBio (Apr 2021)

Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

  • Javier Gutiérrez-Álvarez,
  • José M. Honrubia,
  • Raúl Fernández-Delgado,
  • Li Wang,
  • Carlos Castaño-Rodríguez,
  • Sonia Zúñiga,
  • Isabel Sola,
  • Luis Enjuanes

DOI
https://doi.org/10.1128/mBio.00103-21
Journal volume & issue
Vol. 12, no. 2

Abstract

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The emergence of the new highly pathogenic human coronavirus SARS-CoV-2 that has already infected more than 80 million persons, killing nearly two million of them, clearly indicates the need to design efficient and safe vaccines protecting from these coronaviruses. Modern vaccines can be derived from virus-host interaction research directed to the identification of signaling pathways essential for virus replication and for virus-induced pathogenesis, in order to learn how to attenuate these viruses and design vaccines.