Revista de Ciencias Médicas de Pinar del Río (Jul 2018)
In Silico Analysis of the Feasibility of Mutation of Biological Systems
Abstract
Introduction: in Bioinformatics the goal of the researchers involves the achievement of computerize models for biological processes that approach the real behavior, all this inserted in a discipline known as Biology Systems. In silico analysis in this area of the biological sciences relies on the use of mathematical-computerize methods. Within the analysis in biological systems it is of interest to be able to compare the structure of different organisms. In this comparison, the metabolism of different organisms will be taken into account, as well as the topology of their associated metabolic network. This comparison serves to select the species or to strain the best that suits a particular application. Objective: to analyze the viability of the mutation of a biological system to assume the functions of another. Method: BioOpt computer systems were used for this analysis, which focuses on the analysis of the flow balance, using linear programming as a mathematical support, and CompNet, which compares metabolic networks according to several metrics of similarity and the necessary transformations to take from one metabolic network to another. Results: a comparison was performed between two biological systems, being able to determine the essential reactions within the metabolism of these organisms and from them which ones had to be modified and which ones eliminated to achieve the mutation from one organism to another. Conclusions: this work shows the in silico analysis that helps to determine whether it is practicable or not to perform the genetic manipulation of an organism to assume functions that are defined in another.
