Serum malondialdehyde as a marker of oxidative stress in rheumatoid arthritis

Abstract

Abstract Background A well-recognized connection was found between oxidative stress and rheumatoid arthritis (RA). Since autoimmune illness, as RA is typified by persistent systemic inflammation, oxidative stress indicators offer a promising extra option for evaluating the activity and prognosis of RA. Aim To assess serum malondialdehyde (MDA) level as a marker of oxidative stress in RA patients concerning disease activity. Results This case–control study revealed a statistically significant increase among the patient group than the control group regarding serum MDA. MDA positively correlated with ESR, CRP, DAS-28 score, and morning stiffness. The optimal cut-off point of serum MDA recognized patient group was > 16.21 nmol/ml with a sensitivity of 100% and specificity of 100.0%. Conclusion Measuring MDA levels in RA patients may be useful for monitoring their activity level and oxidative stress.

Keywords

• Rheumatoid arthritis
• Serum malondialdehyde
• Oxidative stress
• Disease activity