Nature Communications (Sep 2020)

Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope

  • Edward Geisinger,
  • Nadav J. Mortman,
  • Yunfei Dai,
  • Murat Cokol,
  • Sapna Syal,
  • Andrew Farinha,
  • Delaney G. Fisher,
  • Amy Y. Tang,
  • David W. Lazinski,
  • Stephen Wood,
  • Jon Anthony,
  • Tim van Opijnen,
  • Ralph R. Isberg

DOI
https://doi.org/10.1038/s41467-020-18301-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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A unique cell envelope contributes to the antibiotic resistance of the pathogen Acinetobacter baumannii. Here, Geisinger et al. identify A. baumannii mutants with altered antibiotic susceptibility, infer the function of uncharacterized proteins involved in envelope synthesis, and predict antibiotic synergies.