Advanced Science (Jun 2021)
Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection
- James D. Byrne,
- Cameron C. Young,
- Jacqueline N. Chu,
- Jennifer Pursley,
- Mu Xian Chen,
- Adam J. Wentworth,
- Annie Feng,
- Ameya R. Kirtane,
- Kyla A. Remillard,
- Cindy I. Hancox,
- Mandar S. Bhagwat,
- Nicole Machado,
- Tiffany Hua,
- Siddartha M. Tamang,
- Joy E. Collins,
- Keiko Ishida,
- Alison Hayward,
- Sarah L. Becker,
- Samantha K. Edgington,
- Jonathan D. Schoenfeld,
- William R. Jeck,
- Chin Hur,
- Giovanni Traverso
Affiliations
- James D. Byrne
- Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA
- Cameron C. Young
- Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA
- Jacqueline N. Chu
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Jennifer Pursley
- Division of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA
- Mu Xian Chen
- Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA
- Adam J. Wentworth
- Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA
- Annie Feng
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Ameya R. Kirtane
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Kyla A. Remillard
- Division of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA
- Cindy I. Hancox
- Department of Radiation Oncology Dana‐Farber Cancer Institute/Brigham and Women's Hospital 44 Binney St. Boston MA 02115 USA
- Mandar S. Bhagwat
- Division of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA
- Nicole Machado
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Tiffany Hua
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Siddartha M. Tamang
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Joy E. Collins
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Keiko Ishida
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Alison Hayward
- David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA
- Sarah L. Becker
- Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA
- Samantha K. Edgington
- Division of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA
- Jonathan D. Schoenfeld
- Department of Radiation Oncology Dana‐Farber Cancer Institute/Brigham and Women's Hospital 44 Binney St. Boston MA 02115 USA
- William R. Jeck
- Department of Pathology Duke University Durham NC 27710 USA
- Chin Hur
- Department of Medicine Columbia University Medical Center 622 West 168th Street, PH 9‐105 New York NY 10032 USA
- Giovanni Traverso
- Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA
- DOI
- https://doi.org/10.1002/advs.202100510
- Journal volume & issue
-
Vol. 8,
no. 12
pp. n/a – n/a
Abstract
Abstract Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D‐printed GI radioprotective devices composed of high‐Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost‐effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.
Keywords
- 3D printing
- dosimetric analysis
- radiation attenuation
- radiation‐induced mucositis
- radiation proctitis
- radioprotective devices
