Nature Communications (Apr 2022)

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins

  • Georg Petkau,
  • Twm J. Mitchell,
  • Krishnendu Chakraborty,
  • Sarah E. Bell,
  • Vanessa D´Angeli,
  • Louise Matheson,
  • David J. Turner,
  • Alexander Saveliev,
  • Ozge Gizlenci,
  • Fiamma Salerno,
  • Peter D. Katsikis,
  • Martin Turner

DOI
https://doi.org/10.1038/s41467-022-29979-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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RNA binding proteins (RBP) have a function in T cell activation and differentiation. Here the authors show that in the absence of two RBPs, ZFP36 and ZFP36L1, T cells acquire more rapidly superior effector capabilities, showing a limiting function for RBP in T cell activation and differentiation.