Nature Communications (Apr 2022)
The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins
Abstract
RNA binding proteins (RBP) have a function in T cell activation and differentiation. Here the authors show that in the absence of two RBPs, ZFP36 and ZFP36L1, T cells acquire more rapidly superior effector capabilities, showing a limiting function for RBP in T cell activation and differentiation.