Nature Communications (May 2017)

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

  • Alexander Rouvinski,
  • Wanwisa Dejnirattisai,
  • Pablo Guardado-Calvo,
  • Marie-Christine Vaney,
  • Arvind Sharma,
  • Stéphane Duquerroy,
  • Piyada Supasa,
  • Wiyada Wongwiwat,
  • Ahmed Haouz,
  • Giovanna Barba-Spaeth,
  • Juthathip Mongkolsapaya,
  • Félix A. Rey,
  • Gavin R. Screaton

DOI
https://doi.org/10.1038/ncomms15411
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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The immunodominant epitope of dengue virus envelope protein (E) induces poorly neutralizing antibodies, which poses a problem for vaccine development. Here, the authors engineer covalently locked E dimers exposing an epitope that has been shown to induce potent and broadly neutralizing antibodies.