Nature Communications (Jan 2021)
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
- Cyrielle Fougeroux,
- Louise Goksøyr,
- Manja Idorn,
- Vladislav Soroka,
- Sebenzile K. Myeni,
- Robert Dagil,
- Christoph M. Janitzek,
- Max Søgaard,
- Kara-Lee Aves,
- Emma W. Horsted,
- Sayit Mahmut Erdoğan,
- Tobias Gustavsson,
- Jerzy Dorosz,
- Stine Clemmensen,
- Laurits Fredsgaard,
- Susan Thrane,
- Elena E. Vidal-Calvo,
- Paul Khalifé,
- Thomas M. Hulen,
- Swati Choudhary,
- Michael Theisen,
- Susheel K. Singh,
- Asier Garcia-Senosiain,
- Linda Van Oosten,
- Gorben Pijlman,
- Bettina Hierzberger,
- Tanja Domeyer,
- Blanka W. Nalewajek,
- Anette Strøbæk,
- Magdalena Skrzypczak,
- Laura F. Andersson,
- Søren Buus,
- Anette Stryhn Buus,
- Jan Pravsgaard Christensen,
- Tim J. Dalebout,
- Kasper Iversen,
- Lene H. Harritshøj,
- Benjamin Mordmüller,
- Henrik Ullum,
- Line S. Reinert,
- Willem Adriaan de Jongh,
- Marjolein Kikkert,
- Søren R. Paludan,
- Thor G. Theander,
- Morten A. Nielsen,
- Ali Salanti,
- Adam F. Sander
Affiliations
- Cyrielle Fougeroux
- AdaptVac Aps
- Louise Goksøyr
- AdaptVac Aps
- Manja Idorn
- Department of Biomedicine, Aarhus University
- Vladislav Soroka
- ExpreS2ion Biotechnologies Aps
- Sebenzile K. Myeni
- Department of Medical Microbiology, Leiden University Medical Center
- Robert Dagil
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Christoph M. Janitzek
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Max Søgaard
- ExpreS2ion Biotechnologies Aps
- Kara-Lee Aves
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Emma W. Horsted
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Sayit Mahmut Erdoğan
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Tobias Gustavsson
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Jerzy Dorosz
- ExpreS2ion Biotechnologies Aps
- Stine Clemmensen
- ExpreS2ion Biotechnologies Aps
- Laurits Fredsgaard
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Susan Thrane
- AdaptVac Aps
- Elena E. Vidal-Calvo
- VAR2pharmaceuticals
- Paul Khalifé
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Thomas M. Hulen
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Swati Choudhary
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Michael Theisen
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Susheel K. Singh
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Asier Garcia-Senosiain
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Linda Van Oosten
- Department of Plant Sciences, Laboratory of Virology
- Gorben Pijlman
- Department of Plant Sciences, Laboratory of Virology
- Bettina Hierzberger
- ExpreS2ion Biotechnologies Aps
- Tanja Domeyer
- ExpreS2ion Biotechnologies Aps
- Blanka W. Nalewajek
- ExpreS2ion Biotechnologies Aps
- Anette Strøbæk
- ExpreS2ion Biotechnologies Aps
- Magdalena Skrzypczak
- ExpreS2ion Biotechnologies Aps
- Laura F. Andersson
- ExpreS2ion Biotechnologies Aps
- Søren Buus
- Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Anette Stryhn Buus
- Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Jan Pravsgaard Christensen
- Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Tim J. Dalebout
- Department of Medical Microbiology, Leiden University Medical Center
- Kasper Iversen
- Department of Cardiology, Herlev Hospital
- Lene H. Harritshøj
- Department of Clinical Immunology, Copenhagen University Hospital
- Benjamin Mordmüller
- Universitätsklinikum Tübingen, Institut für Tropenmedizin
- Henrik Ullum
- Department of Cardiology, Herlev Hospital
- Line S. Reinert
- Department of Biomedicine, Aarhus University
- Willem Adriaan de Jongh
- AdaptVac Aps
- Marjolein Kikkert
- Department of Medical Microbiology, Leiden University Medical Center
- Søren R. Paludan
- Department of Biomedicine, Aarhus University
- Thor G. Theander
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Morten A. Nielsen
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Ali Salanti
- Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital
- Adam F. Sander
- AdaptVac Aps
- DOI
- https://doi.org/10.1038/s41467-020-20251-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.
