The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar; Román González-Prieto; Zhenyu Xiao; Matty Verlaan-de Vries; Alfred C. O. Vertegaal

doi:10.1038/s41467-017-01900-x

Nature Communications (Nov 2017)

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar,
Román González-Prieto,
Zhenyu Xiao,
Matty Verlaan-de Vries,
Alfred C. O. Vertegaal

Affiliations

Ramesh Kumar: Department of Molecular Cell Biology, Leiden University Medical Center
Román González-Prieto: Department of Molecular Cell Biology, Leiden University Medical Center
Zhenyu Xiao: Department of Molecular Cell Biology, Leiden University Medical Center
Matty Verlaan-de Vries: Department of Molecular Cell Biology, Leiden University Medical Center
Alfred C. O. Vertegaal: Department of Molecular Cell Biology, Leiden University Medical Center

DOI: https://doi.org/10.1038/s41467-017-01900-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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SUMO and ubiquitin are key signal transducers in several cellular processes including the DNA-damage response. Here the authors describe a method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes and identify the SUMO conjugation machinery as direct RNF4 substrates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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