Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts
O A Gromova,
I Yu Torshin,
N K Tetruashvili,
L E Fedotova,
N P Lapochkina
Affiliations
O A Gromova
Federal Research Centre "Information and Management" of the Russian Academy of Sciences; Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation
I Yu Torshin
Federal Research Centre "Information and Management" of the Russian Academy of Sciences
N K Tetruashvili
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
L E Fedotova
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation
N P Lapochkina
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation
An estrogen-like activity is considered to be the main mechanism of action for Cimicifuga extract. At the same time, results of modern studies of molecular composition together with modern fundamental data indicate such critical mechanisms of action as activation of serotoninergic and GABA-ergic ways of neurotransmission, as well as anti-inflammatory and antidiabetic effects. The use of drugs based on C. racemosa extracts is perspective for accompanying replacement hormonal therapy with estrogens due to antineoplastic and osteoprotective effects of standardized C. racemosa extracts.
